OVA challenge model: 1. Reduced AHR in Jα18−/− mice 2. Reduction of the key features of asthma [eosinophilia, high type 2 cytokine (IL-4 and IL-5) production, and high anti-OVA IgE titers] in Jα18−/− mice 3. Restoration of key features upon adoptive transfer of NKT cells. The gene discussed is IGHE; the disease is asthma.