IMiDs exert their immunological functions through several mechanisms, including proliferation and functional enhancement of NK/NKT cells, induction of T-cell co-stimulation and reduction of Treg activity, increased Th1 cytokine production, such as IL-2 and IFN-γ, anti-MM ADCC improvement and enhanced DC maturation and functions (101–103). Here, IL2 is linked to Miyoshi myopathy.