Moreover, a recent study from Botta C et al. interestingly defined an 8-genes signature (IL8, IL10, IL17A, CCL3, CCL5, VEGFA, EBI3, and NOS2) able to identify MGUS/smoldering/symptomatic-MM with 84% accuracy and built a prognostic risk score based on six genes (IFNG, IL2, LTA, CCL2, VEGFA, CCL3), validated in three additional independent datasets (79). This evidence concerns the gene IL2 and Miyoshi myopathy.