Along with the suppression of tumor antigen expression, different mechanisms that involve surface molecules and soluble factors released in the tumor microenvironment, e.g., indoleamine 2,3-dioxygenase (IDO), type I interferons (IFNs) and IFN-γ, galectin-1, have been described in the disruption of immune homeostasis and in the altered balance from effector to regulatory and suppressive cells induced by cancer (7, 9). Here, IDO2 is linked to neoplasm.