DDX41 and neoplasm: An elegant study by Surace et al. (86) showed that local irradiation of melanoma and colon carcinoma developing in mice with a single dose of 20 or 5 Gy resulted in rapid and transient C activation triggered by tumor cells undergoing necrosis, apoptosis, and mitotic catastrophe with the possible contribution of natural IgM Abs bound to necrotic cells.