CD38 and neoplasm: In addition to anti-CD20 Abs, other approved C-fixing Abs directed against various tumor antigens have been recognized to activate C both in vitro and in vivo including anti-CD52 alemtuzumab (75), anti-CD38 daratumumab (76, 77), anti-EGFR cetuximab (78, 79), anti-GD2 dinutuximab (80) and anti-HER2 pertuzumab (81).