Furthermore, the lack of IL-1β in caspase-1/11-deficient mice is accompanied by downregulated hepatic interleukin-17+CD8+ and interferon-γ (IFN-γ)+CD8+ T cells, implying that inflammasome-mediated IL-1β is involved in promoting liver adaptive immunity to control this parasitic infection (46). The gene discussed is IL1B; the disease is parasitic infectious disease.