LGALS1 and cancer: We highlight that, the major source of extracellular Gal-1 in these experimental settings are tumor cells that almost saturate the extracellular medium by the secretion of high quantities of Gal-1 [dosed by ELISA at levels of 20 ng/mL, supported also by the high cellular levels of Gal-1 shown in Figure 1, and evaluated in patients in our previous study (30) and reported at high levels in the serum of cancer patients (47–50)].