Several cytokines and chemokines, including IL-2 (82), IL-6 (83), IFNα (84), IFNγ (84), and TWEAK (85), are upregulated in the CSF of SLE patients, and many of these immune mediators have been investigated as potential biomarkers (86). Here, TNFSF12 is linked to systemic lupus erythematosus.