We observed that HT patients who converted early from MMF to EVL (EVL-E group) showed a significant increase of cells expressing cytotoxic molecules (granzyme B, p = 0.001; perforin, p < 0.001) and greater frequency of cells producing the pro-inflammatory cytokine IFN-γ (p = 0.002, Figure 3B). This evidence concerns the gene PRF1 and hematocrit.