PTX3 and Hyperoxaluria: Additionally, the investigation of different strains and sexes revealed, that decreased PTX3 protein expression associates with stone formation in some animals (C57BL/6N male and female), whereas other animals, that are not susceptible for hyperoxaluria-induced nephrocalcinosis, did either not show any PTX3 protein regulation (CD-1 male and female) or upregulated PTX3 under hyperoxaluric conditions (Ptx3-competent mice of the mixed B6;129 background).