A detailed phenotype analysis revealed profound and progressive nephrocalcinosis-related tubular injury in Periodic acid-Schiff (PAS)-stained kidney sections (Figures 4A,B) with CaOx crystal plugs (Figure 4C) in dilated tubules in Ptx3−/− but not in Ptx3+/+ B6;129 mice. Here, PTX3 is linked to nephrocalcinosis.