We selected the B6;129-Ptx3tm1Mant mice that has global PTX3-deficiency to unravel the role of this pentraxin in CaOx crystal aggregation-related disease, i.e., in a model resembling the kidney phenotype of primary hyperoxaluria type I or other forms of progressive nephrocalcinosis. The gene discussed is PTX3; the disease is primary hyperoxaluria type 1.