NFKB1 and psoriasis: Most of the psoriasis-linked mutations harbored in CARMA2sh produced an enhanced activity of NF-κB transcription factor in luciferase assays, with a consequent up-regulation of NF-κB-induced inflammatory transcripts in keratinocytes, such as CXCL8, CCL20, IL8, and IL6, confirming the crucial role played by this transcription factor in epithelial homeostasis (27, 28).