The psoriasis-associated CARMA2sh mutants Glu138Ala and Glu142Gly also escape the negative regulation exerted by two novel CARMA2sh interactors identified by two-hybrid screening in yeast, namely the serine/threonine kinase Unc-51 Like Autophagy Activating Kinase 2 (ULK2) and the E3 ubiquitin ligase Ring Finger protein 7 (RNF7) (57–59). Here, ULK2 is linked to psoriasis.