Most of the psoriasis-linked mutations harbored in CARMA2sh produced an enhanced activity of NF-κB transcription factor in luciferase assays, with a consequent up-regulation of NF-κB-induced inflammatory transcripts in keratinocytes, such as CXCL8, CCL20, IL8, and IL6, confirming the crucial role played by this transcription factor in epithelial homeostasis (27, 28). This evidence concerns the gene CXCL8 and psoriasis.