A recent paper analyzing DLBCL by genetic subtype based on clusters of genetic changes showed that TRAF3 gene loss is frequently, although not exclusively, associated with mutations in BCL6 and Notch2 (BN2 subtype) and Notch1 (N1 subtype) of DLBCL (111). The gene discussed is TRAF3; the disease is diffuse large B-cell lymphoma.