CXCR2 and familial pancreatic carcinoma: - TANs are recruited to orthotopic pancreatic tumor sites via the CXCR2 axis; numbers of CXCR2+ neutrophils in pancreatic cancer patients correlate with prognosis - In an orthotopic PDAC model CXCR2 blockade prevents TAN mobilization from peripheral blood and increases effector T cell numbers in the tumor