PGF and hypertensive disorder: Overexpression of the soluble isoform of the human VEGF receptor, sFLT1, in mouse embryos induces pre-eclampsia like symptoms in pregnant dams, including IUGR, hypertension, and proteinuria, which can be ameliorated by PGF induction suggesting that PGF works antagonistically with sFLT1 to regulate placental angiogenesis (94).