GPER1 and neoplasm: Moreover, as signaling via GPER and HER2 are known to trigger MAP-Kinases activation, and activated MAP-Kinases had been related to SIRT1 augmented activity, this interplay provides an additional framework for the promotion of both tumor ER-independence and EMT progression, potentially offering opportunity to develop tailored strategies, which would come particularly useful for the case of TNBC.