PLOD1 and Alzheimer disease: However, as previously discussed above, downregulation of peripheral LH in the OVX model lead to CAMKII autophosphorylation at Thr 286 and CAMKII dependent GluR1 Ser 831 phosphorylation (58), inhibition of GSK3β and upregulation of β-catenin in 3X Tg mouse model of AD (59), and improved cognitive function.