Our previous studies demonstrated that seizures during developmental period lead to long-term up-regulation of zinc ion transporters ZnT-3, MT-3, lipid transporters ApoE and clusterin, and ACAT-1 (a catalytic esterification of cholesterol and long chain fatty acids to form cholesterol Ester mitochondrial localization enzyme) in hippocampus, accompanied by abnormal mossy fiber sprouting and cognitive impairment. The gene discussed is SLC30A3; the disease is Cognitive impairment.