HRC and dilated cardiomyopathy: One of these proteins, namely histidine-rich calcium binding protein (HRC) has attracted considerable attention over the past decade, since the identification of the HRC Ser96Ala gene variant was associated with increased risk for malignant arrhythmias and sudden cardiac death (SCD) in dilated cardiomyopathy patients (Arvanitis et al., 2008, 2011; Pritchard and Kranias, 2009).