The importance of genetic background on the penetrance of lipodystrophy was recently illustrated in a large population-level genetic study in which 53 loci linked to an insulin resistance phenotype (i.e., high fasting insulin levels adjusted for BMI, low HDL cholesterol levels, and high triglyceride levels) were also associated with a limited peripheral adipose tissue expandability (Lotta et al., 2017). Here, INS is linked to lipodystrophy.