The clinical diagnosis of partial lipodystrophy, rather than generalized lipodystrophy, was based on the loss of adipose tissue mainly in the extremities and the leptin levels (27.7 ng/ml; normal range 3.7–11.1 ng/ml), which indicates the presence of significant amounts of functional adipose tissue (Visser et al., 2011). Here, LEP is linked to generalized lipodystrophy.