LMNA and familial dilated cardiomyopathy: For instance, most of the evidences regarding all the signaling pathways and the specific targets modulated in the striated muscle by a single LMNA mutation rely on a single mouse model containing a knock-in mutation in lamin A/C gene (H222P, Figure 1) causing muscular dystrophy and DCM (Arimura et al., 2005).