In contrast, mice with RAGE knockout (TAC + RAGE-/- group) or RAGE blockade (TAC + FPS-ZM1 group) showed a significant increase of LVEF and LVFS, as well as a significant decrease of LVEDV, LVESV, LVIDd, LVIDs, and LV mass, when compared to control TAC mice with HF assessed at 8 weeks. The gene discussed is AGER; the disease is hydrops fetalis.