In agreement with our results, recent reports have documented a marked endothelial dysfunction associated with a significant vascular pro-oxidant condition in HFD animals (Ketonen et al., 2010; Heinonen et al., 2014; Toral et al., 2015), as well as a decreased SOD1 scavenging activity (Mo et al., 2018). The gene discussed is SOD1; the disease is endothelial dysfunction.