In 2007, a 12-year-old girl who presented with PS, was reported to carry a sporadic missense mutation in sodium voltage-gated channel alpha subunit 1 (SCN1A), the gene encodes a voltage-gated sodium channel that was implicated in the pathology of Dravet Syndrome (Grosso et al., 2007). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.