An FXR agonist inhibited the expression of CYP7A1 and CYP8B1 in ApoE-/- mice and protected mice against atherosclerosis (Mencarelli et al., 2009; Bennett et al., 2013; Miyazaki-Anzai et al., 2014; Miao et al., 2015). This evidence concerns the gene APOE and atherosclerosis.