USP1 and Fanconi anemia: USP1 is a key protein involved in several significant steps in the process of DNA damage response, including regulating the Fanconi anemia pathway (Nijman et al., 2005; Iraia et al., 2013; D'Arcy et al., 2015), the process of translesion synthesis (Huang et al., 2006; Iraia et al., 2013; Villamil et al., 2013), and the process of differentiation in specific cellular contexts (Williams et al., 2011; Villamil et al., 2013).