TP53 and neuroblastoma: Recent research showed that P22077 could induce cell apoptosis and cell proliferation inhibition mediated by p53 in the orthotopic neuroblastoma mouse models of IMR-32, SH-SY5Y, and NGP; since USP7 is overexpressed in neuroblastoma patients, P22077 may be an anti-neuroblastoma agent (Fan et al., 2013; Lim et al., 2016).