AGER and cancer: In addtion, a recent study showed that spautin-1 can also trigger immunogenic cancer cell death in vivo and in vitro by causing mitochondrial oxidative injury rather than autophagy inhibition, also demonstrated that spautin-1 may stimulate an apoptotic pathway that results in immunogenic cancer cell death, in TFAM- and AGER-dependent fashion (Yang et al., 2018).