APOE and Alzheimer disease: The cortex atrophy of hippocampus, amygdala and anterior cingulate have been found in stable MCI patients with APOE ε4 (Hämäläinen et al., 2008; Liu et al., 2010; Tang et al., 2015), and this will extend to frontal and partial and temporal lobe in AD (Hämäläinen et al., 2008).