In Alzheimer’s disease (AD), soluble amyloid-β oligomers and fibrils interact with cell-surface receptors (e.g., integrin, CD14, and the Toll-like receptors TLR2 and TLR4) in microglial cells, and these interactions can also trigger a neuroinflammatory response (Solito and Sastre, 2012; Park et al., 2013; Zhang and Wang, 2014; Heneka et al., 2015). Here, TLR4 is linked to Alzheimer disease.