Arumugam and Parthasarathy (2016) also suggested the presence of autoimmune response in migraine based on their findings of lower levels of Tregs in patients with migraine. However, purinergic mechanisms including expression of CD39 and CD73 which are important for the function of Tregs (Kobie et al., 2006; Borsellino et al., 2007) were not studied. Here, ENTPD1 is linked to migraine disorder.