Disrupted ATP homeostasis can also change the functional role of ATP-driven P2X7 receptors implicated in migraine (Gölöncsér and Sperlágh, 2014; Yegutkin et al., 2016) and in triggering the release of the key pro-inflammatory cytokine, IL-1β (Ferrari et al., 2006; Karmakar et al., 2016). This evidence concerns the gene P2RX7 and migraine disorder.