In healthy controls 10.8 ± 1.32% of the ‘naïve’ CD62L+CD45RO- Tregs were CD73+ and 9.8 ± 0.84% were CD39+, while in patients with migraine these values were significantly lower (3.7 ± 0.64% and 6.5 ± 1.17%, respectively) (Figure 3). The gene discussed is ENTPD1; the disease is migraine disorder.