Considering the low expression of CD39 and CD73 in the CD62L-positive subsets of Tregs (‘naïve’ and CM), and the high level of IL-6 in migraine patients (Khaiboullina et al., 2017), it is possible that Th17 cells may mediate Th cell polarization in lymph nodes and mucosa-associated lymphoid tissues. The gene discussed is SELL; the disease is migraine disorder.