Another gene that is involved in the pathogenesis of LCA (type 12) is rd3 coding for the retinal degeneration 3 (RD3) protein, which is an effective inhibitor of GCAP-mediated activation of GC-E and is involved in trafficking of GC-E from the inner to the outer segment in photoreceptors (Lavorgna et al., 2003; Friedman et al., 2006; Azadi et al., 2010; Peshenko et al., 2011). The gene discussed is RD3; the disease is Leber congenital amaurosis.