ZDHHC8 and schizophrenia: In human patients disruption of the gene encoding the zDHHC8 palmitoyltransferase contributes to schizophrenia and in a mouse knockout of zDHHC8 a reduced branching of axon collaterals was observed further indicating that S-palmitoylation and trafficking might play a role in the formation of neuronal circuits (Mukai et al., 2008, 2015).