FMR1 and fragile X syndrome: Also, it is not surprising that deregulations of expression levels as well as activities of ion channels have been shown in Fmr1-KO neurons (Chen et al., 2003; Meredith et al., 2007; Brown et al., 2010; Deng et al., 2013; Ferron et al., 2014; Zhang et al., 2014; Deng and Klyachko, 2016), some directly implicating VGCC deregulation in FXS (Chen et al., 2003; Meredith et al., 2007; Deng et al., 2013; Ferron et al., 2014; Zhang et al., 2014).