CACNA1A and fragile X syndrome: Also, the altered actin cytoskeleton organization described in different FXS cell lines (Castets et al., 2005; Nolze et al., 2013; Abekhoukh and Bardoni, 2014; Abekhoukh et al., 2017) may explain the reduced membrane expression of Cav2.1, since cytoskeleton is the route for the correct subcellular localization of mRNAs (Bramham and Wells, 2007).