ESR1 and neuroblastoma: We could show in the SH-SY5Y neuroblastoma cell line, a widely used neuronal cell model to investigate hormonal influences of androgens and estrogens (Sarachana et al., 2011; Grassi et al., 2013; Nakaso et al., 2014; Sun et al., 2017), that the effect of DHT and 17β-estradiol on the expression of all three Shanks could be effectively blocked by androgen and estrogen receptor antagonists.