This includes the use of BLEV mice for examining potential therapies in various disease models, where dysregulation of BDNF expression is predicted to contribute to the pathology, such as depression, epilepsy, or Alzheimer's, Huntington's, and Parkinson's disease (Bibel and Barde, 2000; Ginsberg et al., 2017). Here, BDNF is linked to major depressive disorder.