In particular, RAGE is involved in the pathology of Alzheimer’s disease (AD) by activating neuroinflammation (Ramasamy et al., 2009), inducing neuronal dysfunction (Perrone et al., 2012), and mediating the transport of pathological beta-amyloid (Aβ) from the blood into the brain (Yan et al., 2010). The gene discussed is AGER; the disease is early-onset autosomal dominant Alzheimer disease.