The ability of the metal complexes CuII(gtsm) and CuII(atsm) to improve cognition in AD and motor performance in ALS has been attributed to reduction of Aβ oligomers and tau phosphorylation (Crouch et al., 2009), as well as the ability to improve the copper content of the metallo-protein Cu/Zn superoxide dismutase (SOD1) (Roberts et al., 2014) and reduce nitrosative damage (Soon et al., 2011). Here, SOD1 is linked to Alzheimer disease.