Post-mortem studies demonstrated a concept for patterns of TDP-43 pathology in ALS with a sequential progression of pTDP-43 aggregates (Braak et al., 2013), the task remained to investigate if in vivo neuroimaging measures might be identified that were consistent with these patterns of pTDP-43 progression (Kassubek et al., 2018a). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.