In our recent publication, “Adipocyte-specific double knockout of Lkb1 and mTOR protects mice against high-fat diet induced obesity but results in insulin resistance”, published in Journal of Lipid Research, we generated adipocyte-specific Lkb1 and mTOR double knockout (DKO) mice and assessed how genetic knockout of both Lkb1 and mTOR affects adipose tissue development and function in energy homeostasis 5. The gene discussed is MTOR; the disease is obesity disorder.