In PC, overexpression of VASH2 is associated with accelerated tumor malignant transformation and reduced chemosensitivity to gemcitabine.13 Our study also suggests that VASH2 is involved in promoting EMT of HCC cells.14 Therefore, we hypothesized that VASH2 may regulate EMT in PC cells. The gene discussed is VASH2; the disease is hepatocellular carcinoma.