It can also stimulate the EMT by activating two main proteins of the EMT pathways, Akt and NF‐kB.22, 23, 24 The finding that VASH2 can significantly increase the proportion of CD44+ cells suggest that VASH2 may promote the metastasis of PC by increasing the proportion of cancer stem cell‐like cells in PC cells. This evidence concerns the gene CD44 and pachyonychia congenita.