Inhibition of Hedgehog signaling can suppress EMT, invasion, chemo‐resistance, stem‐like properties and metastasis of PC cells.17 Interestingly, overexpression of ZEB1/2 is also associated with these malignant behaviors of PC cells.7 Our findings that overexpression of VASH2 upregulates Hedgehog signaling, and knockdown of VASH2 downregulates Hedgehog signaling strongly suggest that VASH2 promotes malignant behaviors of PC cells via hedgehog signaling. The gene discussed is ZEB1; the disease is pachyonychia congenita.