Previous studies have found that EMT can enhance the invasive, migratory, and metastatic ability of PC cells,8 and these behaviors of PC cells were closely related with cancer stem cell‐like cell populations such as SP cells and CD24+CD44+ cells.20, 21 In agreement with this, we found that VASH2 increased the proportion of SP cells and CD24+ CD44+ cells in PC cells. Here, VASH2 is linked to pachyonychia congenita.