The second patient was a 4.1 year old with a NDD whose primary result (KDM5C; OMIM #314690; GenBank RefSeq NG_008085.2) provided an X‐linked Claes‐Jensen syndrome diagnosis, and the secondary findings result indicated an increased risk of Lynch syndrome based on a pathogenic variant found in MSH6 (OMIM #600678; GenBank RefSeq NG_007111.1). The gene discussed is MSH6; the disease is Neurodevelopmental delay.