They revealed that the stimulation of tumor angiogenesis occurs through ROS upregulation causing activation of HIF1/VEGF-A pathway.45 More recently, some studies revealed that mutant p53 proteins suppress the expression of SLC7A11, a key component of the cystine/glutamate antiporter system xC-, diminishing glutathione synthesis and resulting in redox imbalance.46,47. This evidence concerns the gene TP53 and neoplasm.