TP53 and cancer: As ROS can produce genomic DNA damage,56 it is conceivable that ROS enhancement by mutant p53 may contribute to the induction of genomic DNA damage and genomic instability, which are typical hallmarks of cancer cells bearing mutant TP53 gene.8,57 Intriguingly, from a therapeutic point of view, the intracellular ROS enhancement driven by mutant p53 might represent an “Achilles heel” of cancer cells carrying mutant TP53 gene, as revealed by the mutp53-dependent acquisition of cell sensitivity to H2O2 treatment.