While reduced FLP abundance and outgrowth deficiency of BCC upon Pfn1 KD is consistent with previously reported LOF phenotypes of other Pfn1-binding actin-cytoskeleton regulatory proteins (such as mDia2 and Ena/VASP),6,7 and may even indirectly suggest possible role of Pfn1’s interaction with those actin-binding proteins, in this context, there is an important distinction between the previous and our findings. Here, DIAPH3 is linked to skin basal cell carcinoma.