PFN1 and neoplasm: At FDR ≤ 10%, we identified 2 gene expression signatures from JAK2 (Janus Kinase 2—a promoter of STAT signalling with oncogenic function) and PTEN (Phosphatase and Tensin homolog—an antagonist of PI3K signalling and a prominent tumour suppressor) KD studies that were significantly aligned to the Pfn1 KD transcriptome for both upregulated and downregulated genes.