Reasons that the other 36 patients were not enrolled to the treatment study included the following: (a) found to be ineligible; (b) did not need a new treatment initiated before the study ended; (c) no slot available; (d) clinician/patient preference; and (e) tumour tissue was NQO1-negative (an exclusion factor only after institution of the enrolment biomarker). This evidence concerns the gene NQO1 and neoplasm.