Inhibition of amino group transfer from BCAAs to α-ketoglutarate and a blockage in nucleotide synthesis were reported in ME3-deleted PDAC cells in association with downregulation of BCATm expression.15 Similar findings were described in NSCLC, where extraction of nitrogen from BCAAs was important for de novo amino acid and nucleotide biosynthesis. The gene discussed is ME3; the disease is non-small cell lung carcinoma.