MYCN and neuroblastoma: From previous reports, we could classify neuroblastoma cell lines with no or low N-Myc expression (SHEP, SKNAS), with N-Myc amplification (IMR32, SK-N-BE(2)C and SH-SY5Y) and with high N-Myc amplification (KELLY).41–44 Sensitivity of the neuroblastoma cell lines to C1A was found to be dependent on N-Myc protein expression, with KELLY being the most sensitive cell line (Fig. 6a).