MYC and neuroblastoma: For instance, Nawrocki et al.40 have shown, in human foreskin fibroblasts transfected with Myc, increased protein synthesis and aggresome/autophagosome formation alongside increased HDAC6 expression, suggesting that further that HDAC6 is a direct Myc transcriptional target,40 although our current work in neuroblastoma cells showed that C1A increased Myc mRNA level and decreased  its expression level.