MYCBP2, also known as PAM (protein associated with myc), is an adenylyl cyclase and an E3 ubiquitin ligase that is a highly conserved protein that interacts directly with the transcriptional activating domain of myc.35,36 One study has reported MYCBP2 as potential target for miR-1247 in a prostate cancer model37 but not validated in clinical human tissues as has been shown in the current study. Here, MYC is linked to Familial prostate cancer.