In some cases, internalisation of the activated receptor (i.e. EGFR) and endocytic trafficking enables specific signalling pathways from intracellular sites.34 In this regard, the regulation of IL13Rα2 expression by mutant variant EGFRvIII in glioblastoma cells might suggest some association between both receptors.3 It is unclear whether IL13Rα2 trafficking and recycling is critical for IL-13 signalling as it occurs for EGFR and its ligands. The gene discussed is EGFR; the disease is glioblastoma.