TGFB1 and neoplasm: On the other hand, targeting IL13Rα2 expression on immune cells of the tumour microenvironment contributes to the restoration of the immunosurveillance mechanisms caused by the loss of TGFβ1 production.27 Therefore, blocking IL13Rα2 might reduce mouse mortality through two different mechanisms, either a direct effect on the tumoural cells or an indirect effect on myeloid cells (CD11bhigh/Gr-1intermediate) for restoration of cellular immunity.