IL13RA2 and colorectal cancer: IL13Rα2 is present in two forms: a membrane signalling receptor and a soluble form with no signalling activity.13 The binding of IL-13 to IL13Rα2 triggers different cellular pathways, STAT6-independent, to promote migration, invasion and survival of colorectal cancer metastatic cells.1 Initially, the strong binding affinity of IL-13 to IL13Rα2 was interpreted as a way to sequester IL-13 and provoke its downregulation.14 However, the decoy concept does not explain IL13Rα2 overexpression in cancer cells and its signalling capacity.