For example, polypyrimidine tract-binding protein (PTBP1/PTB/hnRNP I), an RBP regulating pre-mRNA processing in the nucleus and mRNA translation in the cytoplasm (Kafasla et al., 2012, Keppetipola et al., 2012), is upregulated in several types of cancer (Cheung et al., 2009, He et al., 2014, Wang et al., 2017). The gene discussed is PTBP1; the disease is cancer.