To study the contribution of the known SNPs to the risk of POAG in GIGA,we calculated a multilocus Genetic Risk Score (GRS) based on 15 known SNPs.Three known SNPs for TXNRD2, CDKN2B-AS1, andTMCO1 were replaced by the proxies that were identified bythe local replication approach described above. The gene discussed is TXNRD2; the disease is open-angle glaucoma.