CD8A and lymphopenia: One liver cancer case was lymphophenic at multiple visits, with CD4 and CD8 cell counts < 300 and 100, respectively (Fig. 1, left panels); these observations together with our finding that FIB-4 > 1.45 is more frequent among subjects with CD4 nadir < 500 compared to those with CD4 nadir ≥ 500 are consistent with other studies linking lymphopenias with advanced liver disease [16, 18].