In these experiments, treatment of MC-38 tumor-bearing mice with α-PD-1/α-PD-L1 or HDC/α-PD-1/α-PD-L1 tended to increase the fraction of intratumoral CD8+ T cells and significantly increased the fraction of CD8+ T cell with an effector phenotype (Supplementary Fig. 7b, c). Here, CD274 is linked to neoplasm.