Our study also found that expression of vessel-associated integrin-β1, as well as ECM proteins col IV and laminin, and perivascular astrocytes were all reduced by the lack of PTX3, 28 days after cerebral ischaemia, further suggesting that cerebrovascular ECM remodelling regulated by PTX3 may be a key step for restoration of CBF after stroke. The gene discussed is PTX3; the disease is stroke disorder.