However, we believe that contributions of pro-IL-1β and pro-IL-18 downregulation to colitis are none or negligible because impact of Rev-erbα on inflammasome activation (i.e., activation of caspase-1 and maturation of IL-1β) and experimental colitis is highly Nlrp3-dependent (Fig. 7). Here, NLRP3 is linked to colitis.